Spinosad Biological InsecticidesI/high quality/lower price CAS NO.168316-95-8

Why choose us

--Advanced production equipments and strict production management according to GMP regulation are the solid base of spinosad uniformity.

--The strong R&D team is supporting us to keep spinosad competitiveness.

--The lab with complete facilities and experienced analysts is the guarantee of high quality of spinosad.

--The efficient system of logistics and warehouse management are the guarantee of delivering spinosad on time,with the perfect conditions.

Spinosad (Biological Insecticides)

CAS NO.: 131929-60-7;168316-95-8

Molecular formula：C41H65NO10

Molecular weight：731.9555

Packing：1KG/PACK

Structural formula：

Key word:

spinosyn A;spinosyn D; Mixture of Spinosyn A and Spinosyn D

What is Spinosad

Spinosad is an insecticide based on chemical compounds found in the bacterial species Saccharopolyspora spinosa. The genus Saccharopolyspora was discovered in 1985 in isolates from crushed sugarcane which produce yellowish-pink aerial hyphae, with bead-like chains of spores enclosed in a characteristic hairy sheath.This genus is defined as aerobic, Gram-positive, nonacid-fast actinomycetes with fragmenting substrate mycelium. S. spinosa was isolated from soil collected inside a nonoperational sugar mill rum still in the Virgin Islands. Spinosad is a mixture of chemical compounds in the spinosyn family that has a generalized structure consisting of a unique tetracyclic ring system attached to an amino sugar (D-forosamine) and a neutral sugar (tri-Ο-methyl-L-rhamnose).Spinosad is relatively nonpolar and not easily dissolved in water.

Spinosad is a novel mode-of-action insecticide derived from a family of natural products obtained by fermentation of S. spinosa. Spinosyns occur in over 20 natural forms, and over 200 synthetic forms (spinosoids) have been produced in the lab.Spinosad contains a mix of two spinosoids, spinosyn A, the major component, and spinosyn D (the minor component), in a roughly 17:3 ratio.

Spinosad is a protein-based insecticide derived by fermentation of the Actinomycete bacterium Saccharopolyspora spinosa (Milles, 2003), and is a natural mixture of spinosyn A and spinosyn D. 

mode of action of Spinosad：

Spinosad is highly active, by both contact and ingestion, in numerous insect species.Its overall protective effect varies with insect species and life stage. It affects certain species only in the adult stage, but can affect other species at more than one life stage. The species subject to very high rates of mortality as larvae, but not as adults, may gradually be controlled through sustained larval mortality. The mode of action of spinosoid insecticides is by a neural mechanism.The spinosyns and spinosoids have a novel mode of action, primarily targeting binding sites on nicotinic acetylcholine receptors (nAChRs) of the insect nervous system that are distinct from those at which other insecticides have their activity. Spinosoid binding leads to disruption of acetylcholine neurotransmission. Spinosad also has secondary effects as a γ-amino-butyric acid (GABA) neurotransmitter agonist. It kills insects by hyperexcitation of the insect nervous system. Spinosad so far has proven not to cause cross-resistance to any other known insecticide.

Benefits of Spinosad：

Spinosad is a broad spectrum of biological pesticide. Its insecticidal activity is better than organophosphorus carbamate cyclopentadiene and other pesticides. It can effectively control the pests including lepidoptera Diptera and thysanoptera pests, and at the same time. It also has certain toxic effect to coleoptera Orthoptera hymenoptera spectacle, etc Fleas orders, Dermaptera and tooth worm to certain species of insect pests, but for sucking mouthparts insects and mites control effect is not ideal.

Usage of Spinosad：

Spinosad has been used around the world for the control of a variety of insect pests, including Lepidoptera, Diptera, Thysanoptera, Coleoptera, Orthoptera, and Hymenoptera, and many others. It was first registered as a pesticide in the United States for use on crops in 1997.Its labeled use rate is set at 1 ppm (1 mg a.i./kg of grain) and its maximum residue limit (MRL) or tolerance is set at 1.5 ppm. Spinosad’s widespread commercial launch was deferred, awaiting final MRL or tolerance approvals in a few remaining grain-importing countries. It is considered a natural product, thus is approved for use in organic agriculture by numerous nations. Two other uses for spinosad are for pets and humans. Spinosad has recently been used in oral preparations to treat C. felis, the cat flea, in canines and felines; the optimal dose set for canines is reported to be 30 mg/kg.

Trade names include Comfortis and Trifexis (which also includes milbemycin oxime) (both brands treat adult fleas on pets; the latter also prevents heartworm disease), and Natroba (for human head lice). It is commonly used to kill thrips.

Note of Spinosad：

1. It may be toxic to fish or other aquatic organisms and should avoid contaminating water sources and ponds.

2. The last time to apply the medicine is 7 days before the harvest, avoiding rain in 24 hours after spraying.

Spinosad has high efficacy, a broad insect pest spectrum, low mammalian toxicity, and a good environmental profile, a unique feature of the insecticide compared to others currently used for the protection of grain products.[5] It is regarded as natural product-based, and approved for use in organic agriculture by numerous national and international certifications. Spinosad residues are highly stable on grains stored in bins, with protection ranging from 6 months to 2 years.[clarification needed] Ecotoxicology parameters have been reported for spinosad, and are:

• in rat (Rattus norvegicus Bergenhout, 1769), acute oral: LD50 >5000 mg/kg (nontoxic)

• in rat (R. norvegicus), acute dermal: LD50 >2000 mg/kg (nontoxic)

• in California quail (Callipepla californica Shaw, 1798), oral toxicity: LD50 >2000 mg/kg (nontoxic)

• in duck (Anas platyrhynchos domestica Linnaeus, 1758), dietary toxicity: LC50 >5000 mg/kg (nontoxic)

• in rainbow trout (Oncorhynchus mykiss Walbaum, 1792), LC50-96h = 30.0 mg/l (slightly toxic)

• in Honeybee (Apis mellifera Linnaeus, 1758), LD50 = 0.0025 mg/bee (highly toxic if directly sprayed on, little toxicity of dried residues).

Chronic exposure studies failed to induce tumor formation in rats and mice; mice given up to 51 mg/kg/day for 18 months resulted in no tumor formation. Similarly, administration of 25 mg/kg/day to rats for 24 months did not result in tumor formation.

Specification/technical data sheet                          

How to test assay of Spinosad

HPLC:Under the same chormatographic conditions.The relative deviations between the retention times for spinpsad respectvely in the chromatograms obtained with the reference solution and the sample solution should not exceed 1.5%.

Storage:

Preserve in tight,light-resistant containers,store at 25℃,excursions permitted between 15-30℃. Keep out of reach of children.

Shelf life:  

24 months when properly stored in original packing

Why choose us

--Advanced production equipments and strict production management according to GMP regulation are the solid base of spinosad uniformity.

--The strong R&D team is supporting us to keep spinosad competitiveness.

--The lab with complete facilities and experienced analysts is the guarantee of high quality of spinosad.

--The efficient system of logistics and warehouse management are the guarantee of delivering spinosad on time,with the perfect conditions.

--The efficient system of logistics and warehouse management are the guarantee of delivering spinosad on time,with the perfect conditions.

FAQ:

Who are API&HERB GROUP

API&HERB GROUP is engaged in human health all over the world.The API Biopharm and HERB Biopharm are mainly held by API&HERB group.API biopharm is a high-new-tech enterprises and national sterioid hormone manufacturer.

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What’s the MOQ

Sample will be free accordingly,with freight collect.MOQ is 0.5kg .